Published Research


Research topics:

Predicting erosions

Predicting erosive disease in rheumatoid arthritis. A longitudinal study of changes in bone density using digital X-ray radiogrammetry: a pilot study. Stewart A, Mackenzie LM, Black AJ, Reid DM. Rheumatology (Oxford). 2004 Dec;43(12):1561-4. Epub 2004 Aug 24.

Digital X-ray Radiogrammetry: A Promising Predictor Of Joint Destruction In Early Ra. Kristina Forslind, Annelies Boonen, Ingiäld Hafström, Kristina Albertsson, Björn Svensson. Arthritis Rheum 2007 (suppl) ACR 2007

Hand Bone Loss in Rheumatoid Arthritis (RA) the First Year of Follow-Up Predicts Subsequent Radiographic Damage. Mari Hoff, Sigrid Ødegård, Till Uhlig, Anders Strand, Tore K. Kvien, Robert Landewé Desiree van der Heijde, Glenn Haugeberg Arthritis Rheum 2006 (suppl) ACR 2006

Bone loss of the hands in rheumatoid arthritis (RA) during the first 2 years predicts subsequent radiographic hand joint damage at 5 and 10 years. M. Hoff, S. Ødegård, T.K. Kvien, R. Landewé, D. Van der Heijde, T. Uhlig, A. Strand, G. Haugeberg. Ann Rheum Dis 2006 (suppl) EULAR 2006

Hand bone loss in the first three months and baseline MRI bone marrow edema predicts one-year change in MRI erosions in early Rheumatoid Arthritis patients P. Bøyesen, E.A. Haavardsholm, M. Østergaard, G. Haugeberg, A. Schilvold, T.K. Kvien. Ann Rheum Dis 2007 (suppl) EULAR 2007

Treatment monitoring/Randomized studies

Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis: results from a randomized placebo-controlled trial. Haugeberg G, Strand A, Kvien TK, Kirwan JR. Arch Intern Med. 2005 Jun 13;165(11):1293-7.

Bone Mineral Density (BMD) measured by Digital X-ray Radiogrammetry (DXR) and Dual Energy X-ray Absorptiometry (DEXA) in Patients with Recent Onset Rheumatoid Arthritis (RA) after 1 year of treatment in the BeSt study. M Güler-Yüksel, CF Allaart, FC Breedveld, BAC Dijkmans, WF Lems. Arthritis Rheum 2007 (suppl) ACR 2007

Anti-TNF treatment with adalimumab reduces hand bone loss in early Rheumatoid Arthritis (RA): Explorative analyses from the PREMIER study. Hoff M, Kvien TK, Kälvesten J, Algulin J, Elden A, Haugeberg G. Arthritis Rheum 2007 (suppl) ACR 2007

Digital X-ray Radiogrammetry: A Promising Predictor Of Joint Destruction In Early Ra. Kristina Forslind, Annelies Boonen, Ingiäld Hafström, Kristina Albertsson, Björn Svensson. Arthritis Rheum 2007 (suppl) ACR 2007

Influence of of Alendronate (AL) and Glucocorticoid Treatment on Periarticular and Generalised Bone Loss in Patients with Early Rheumatoid Arthritis (ERA). Relationship to Disease Activity and Radiographic Outcome. Trine W. Jensen, M. S. Hansen, K. Hørslev-Petersen, L. Hyldstrup, B. Abrahamsen, B. Langdahl, B. Zerahn, J. Pødenphant, K. Stengaard-Petersen, P. Junker, M. Østergaard, T. Lottenburger, T. Ellingsen, L. S. Andersen, I. Hansen, H. Skjødt, J. K. Pedersen, U. B. Lauridsen, A. Svendsen, U. Tarp, G. Hansen, H. Lindegaard, A. Carvalho, M. Hetland Arthritis Rheum 2005 (suppl) ACR 2005

Relationship to erosions/Diagnostic performance

Digital X-ray radiogrammetry combined with semiautomated analysis of joint space widths as a new diagnostic approach in rheumatoid arthritis: a cross-sectional and longitudinal study. Bottcher J, Pfeil A, Rosholm A, Petrovitch A, Seidl BE, Malich A, Schafer ML, Kramer A, Mentzel HJ, Lehmann G, Hein G, Kaiser WA. Arthritis Rheum. 2005 Dec;52(12):3850-9.


Computerized Digital Imaging Techniques Provided by Digital X-ray Radiogrammetry as New Diagnostic Tool in Rheumatoid Arthritis. Lehmann G, Mentzel HJ, Hein G, Wolf G, Kaiser WA. J Digit Imaging. 2006 Apr 26; [Epub ahead of print]

Potential clinical relevance of digital radiogrammetry for quantification of periarticular bone demineralization in patients suffering from rheumatoid arthritis depending on severity and compared with DXA. Bottcher J, Malich A, Pfeil A, Petrovitch A, Lehmann G, Heyne JP, Hein G, Kaiser WA. Eur Radiol. 2004 Apr;14(4):631-7. Epub 2003 Nov 5.

Use of digital x ray radiogrammetry in the assessment of joint damage in rheumatoid arthritis. Jawaid WB, Crosbie D, Shotton J, Reid DM, Stewart A. Ann Rheum Dis. 2006 Apr;65(4):459-64. Epub 2005 Aug 26.

Comparison of dual X-ray absorptiometry (DXA), digital X-ray radiogrammetry (DXR), and conventional radiographs in the evaluation of osteoporosis and bone erosions in patients with rheumatoid arthritis. Jensen T, Hansen M, Jensen KE, Podenphant J, Hansen TM, Hyldstrup L. Scand J Rheumatol. 2005;34(1):27-33.

Hand cortical bone mass and its associations with radiographic joint damage and fractures in 50-70 year old female patients with rheumatoid arthritis: cross sectional Oslo-Truro-Amsterdam (OSTRA) collaborative study. Haugeberg G, Lodder MC, Lems WF, Uhlig T, Orstavik RE, Dijkmans BA, Kvien TK, Woolf AD. Ann Rheum Dis. 2004 Oct;63(10):1331-4.

Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry. Bottcher J, Pfeil A, Rosholm A, Soros P, Petrovitch A, Schaefer ML, Seidl BE, Malich A, Hansch A, Wolf G, Kaiser WA. Invest Radiol. 2006 Jan;41(1):36-44.

Danish TIRA Group. Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome. Jensen T, Klarlund M, Hansen M, Jensen KE, Skjodt H, Hyldstrup L; J Rheumatol. 2004 Sep;31(9):1698-708.

Comparisons to other technologies

Hand bone loss as an outcome measure in established rheumatoid arthritis: 2-year observational study comparing cortical and total bone loss. Hoff M, Haugeberg G, Kvien TK Arthritis Res Ther. 2007 Aug 17;9(4):R81 [Epub ahead of print]

Bone loss in unclassified polyarthritis and early rheumatoid arthritis is better detected by digital x ray radiogrammetry than dual x ray absorptiometry: relationship with disease activity and radiographic outcome. Jensen T, Klarlund M, Hansen M, Jensen KE, Podenphant J, Hansen TM, Skjodt H, Hyldstrup L; TIRA Group. Ann Rheum Dis. 2004 Jan;63(1):15-22.

Clinical trial for differentiation between corticoid-induced osteoporosis and periarticular demineralization via digital radiogrammetry in patients suffering from rheumatoid arthritis Bottcher J, Pfeil A, Lehmann G, Heinrich B, Malich A, Hansch A, Petrovitch A, Mentzel HJ, Hein G, Kaiser WA. Z Rheumatol. 2004 Dec;63(6):473-82. German

Potential clinical relevance of digital radiogrammetry for quantification of periarticular bone demineralization in patients suffering from rheumatoid arthritis depending on severity and compared with DXA. Bottcher J, Malich A, Pfeil A, Petrovitch A, Lehmann G, Heyne JP, Hein G, Kaiser WA. Eur Radiol. 2004 Apr;14(4):631-7. Epub 2003 Nov 5.

Peripheral bone status in rheumatoid arthritis evaluated by digital X-ray radiogrammetry and compared with multisite quantitative ultrasound. Bottcher J, Pfeil A, Mentzel H, Kramer A, Schafer ML, Lehmann G, Eidner T, Petrovitch A, Malich A, Hein G, Kaiser WA. Calcif Tissue Int. 2006 Jan;78(1):25-34. Epub 2006 Jan 6.

Comparison of dual X-ray absorptiometry (DXA), digital X-ray radiogrammetry (DXR), and conventional radiographs in the evaluation of osteoporosis and bone erosions in patients with rheumatoid arthritis. Jensen T, Hansen M, Jensen KE, Podenphant J, Hansen TM, Hyldstrup L. Scand J Rheumatol. 2005;34(1):27-33.

Digital radiogrammetry as a new diagnostic tool for estimation of disease-related osteoporosis in rheumatoid arthritis compared with pQCT. Bottcher J, Pfeil A, Heinrich B, Lehmann G, Petrovitch A, Hansch A, Heyne JP, Mentzel HJ, Malich A, Hein G, Kaiser WA. Rheumatol Int. 2005 Aug;25(6):457-64. Epub 2005 Mar 11.

Performance in assessing BMD

Digital X-ray radiogrammetry: a new appendicular bone densitometric method with high precision. Jorgensen JT, Andersen PB, Rosholm A, Bjarnason NH. Clin Physiol. 2000 Sep;20(5):330-5.

Estimation of bone mineral density by digital X-ray radiogrammetry: theoretical background and clinical testing. Rosholm A, Hyldstrup L, Backsgaard L, Grunkin M, Thodberg HH. Osteoporos Int. 2001;12(11):961-9.

Metacarpal index by digital X-ray radiogrammetry: normative reference values and comparison with dual X-ray absorptiometry. Hyldstrup L, Nielsen SP.  J Clin Densitom. 2001 Winter;4(4):299-306.

A technical and clinical evaluation of digital X-ray radiogrammetry. Ward KA, Cotton J, Adams JE. Osteoporos Int. 2003 Jun;14(5):389-95. Epub 2003 Apr 1.

The precision of digital X-ray radiogrammetry compared with DXA in subjects with normal bone density or osteoporosis. Elliot JR, Fenton AJ, Young T, Mansfield A, Burton C, Wilkinson TJ. J Clin Densitom. 2005 Summer;8(2):187-90.

Influence of image-capturing parameters on digital X-ray radiogrammetry. Bottcher J, Pfeil A, Rosholm A, Malich A, Petrovitch A, Heinrich B, Lehmann G, Mentzel HJ, Hein G, Linss W, Kaiser WA. J Clin Densitom. 2005 Spring;8(1):87-94.

The impact of technical conditions of X-ray imaging on reproducibility and precision of digital computer-assisted X-ray radiogrammetry (DXR). Malich A, Boettcher J, Pfeil A, Sauner D, Heyne JP, Petrovitch A, Hansch A, Linss W, Kaiser WA. Skeletal Radiol. 2004 Dec;33(12):698-703. Epub 2004 Oct 9.

Other immunology diseases

The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease. Mentzel HJ, Blume J, Boettcher J, Lehmann G, Tuchscherer D, Pfeil A, Kramer A, Malich A, Kauf E, Hein G, Kaiser WA. Pediatr Radiol. 2006 May;36(5):415-20. Epub 2006 Feb 28.

Direct X-ray radiogrammetry versus dual-energy X-ray absorptiometry: assessment of bone density in children treated for acute lymphoblastic leukaemia and growth hormone deficiency. van Rijn RR, Boot A, Wittenberg R, van der Sluis IM, van den Heuvel-Eibrink MM, Lequin MH, de MuinckKeizer-Schrama SM, Van Kuijk C. Pediatr Radiol. 2006 Mar;36(3):227-32. Epub 2006 Jan 24.

Osteoporosis In Turkish HIV/AIDS patients: comparative analysis by dual energy X-ray absorptiometry and digital X-ray radiogrammetry. Ozcakar L, Guven GS, Unal S, Akinci A. Osteoporos Int. 2005 Nov;16(11):1363-7. Epub 2005 Apr 12.

Digital radiogrammetry of the hand in a pediatric and adolescent Dutch Caucasian population: normative data and measurements in children with inflammatory bowel disease and juvenile chronic arthritis. van Rijn RR, Grootfaam DS, Lequin MH, Boot AM, van Beek RD, Hop WC, van Kuijk C. Calcif Tissue Int. 2004 Apr;74(4):342-50.

Predicting fractures

Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fractures. Bouxsein ML, Palermo L, Yeung C, Black DM Osteoporos Int. 2002 May;13(5):358-65.

Digital x-ray radiogrammetry identifies women at risk of osteoporotic fracture: results from a prospective study. Bach-Mortensen P, Hyldstrup L, Appleyard M, Hindso K, Gebuhr P, Sonne-Holm S. Calcif Tissue Int. 2006 Jul;79(1):1-6. Epub 2006 Jul 24.  

The use of digital X-ray radiogrammetry and peripheral dual energy X-ray absorptiometry in patients attending fracture clinic after distal forearm fracture. Reed MR, Murray JR, Abdy SE, Francis RM, McCaskie AW. Bone. 2004 Apr;34(4):716-9.

Screening for osteoporosis

Identifying postmenopausal women with osteoporosis by calcaneal ultrasound, metacarpal digital X-ray radiogrammetry and phalangeal radiographic absorptiometry: a comparative study. Boonen S, Nijs J, Borghs H, Peeters H, Vanderschueren D, Luyten FP. Osteoporos Int. 2005 Jan;16(1):93-100. Epub 2004 Jun 10.

Normative data

Normative data for digital x-ray radiogrammetry from a female and male german cohort. Bottcher J, Pfeil A, Schafer ML, Petrovitch A, Seidl BE, Mentzel HJ, Lehmann G, Malich A, Heyne JP, Hein G, Wolf G, Kaiser WA. J Clin Densitom. 2006 Jul-Sep;9(3):341-50.

A normative reference database study for Pronosco X-posure System. Black DM, Palermo L, Sorensen T, Jorgensen JT, Lewis C, Tylavsky F, Wallace R, Harris E, Cummings SR. J Clin Densitom. 2001 Spring;4(1):5-12.

Age-related changes in cortical bone mass: data from a German female cohort. Toledo VA, Jergas M. Eur Radiol. 2006 Apr;16(4):811-7. Epub 2005 Oct 8.

Metacarpal index and bone mineral density in healthy African-American women. Shepherd JA, Meta M, Landau J, Sherrer YS, Goddard DH, Ovalle MI, Rosholm A, Genant HK. Osteoporos Int. 2005 Dec;16(12):1621-6. Epub 2005 Jun 10.

Normative values of bone parameters of children and adolescents using digital computer-assisted radiogrammetry (DXR). Malich A, Freesmeyer MG, Mentzel HJ, Sauner D, Boettcher J, Petrovitch A, Behrendt W, Kaiser WA. J Clin Densitom. 2003 Summer;6(2):103-11.

Influence of body constitution on bone mineral density measured by digital radiogrammetry Bottcher J, Pfeil A, Teufl F, Petrovitch A, Lehmann G, Kramer A, Mentzel HJ, Hansch A, Malich A, Hein G, Kaiser WA. Rofo. 2005 Feb;177(2):197-203. German.

Evaluation of bone-mineral density by digital X-ray radiogrammetry (DXR) in pediatric renal transplant recipients. Mentzel HJ, John U, Boettcher J, Malich A, Pfeil A, Vollandt R, Misselwitz J, Kaiser WA. Pediatr Radiol. 2005 May;35(5):489-94. Epub 2004 Dec 29.

Estimation of bone mass of hemodialysis patients by digital radiologic radiogrammetry (DXR) Reyes L, Rodriguez Garcia M, Gomez Alonso C, Megido J, Ruiz de Alegria P, Fonseca A, Gorostidi M, Gago E, Forascepi R, Guerediaga J, Cannata Andia JB.  Nefrologia. 2003;23 Suppl 2:100-5. Review. Spanish.

Response of cortical bone to antiresorptive treatment. Hyldstrup L, Jorgensen JT, Sorensen TK, Baeksgaard L. Calcif Tissue Int. 2001 Mar;68(3):135-9.

See also

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